It was learned from Zhejiang University that Professor Zhang Hong of the Institute of calibration medicine and molecular imaging successfully developed the first set of PET molecular image probe microfluidic modular integrated synthesis system with independent intellectual property rights in China in 12 years.

       This achievement not only greatly expanded the clinical application of pet in individualized and precision medicine, but also provided important support for the research and development of related new drugs.

       As the key of pet and nuclear medicine, the molecular image probe can release radionuclides, make biological marks in the body, find the focus location for doctors and researchers, and help to achieve accurate diagnosis and treatment of major diseases such as tumor, cardiovascular and neuropsychiatric diseases. However, specific probes are needed to observe specific biochemical processes. At present, there are more than 100 kinds of such molecular image probes in the world. With the continuous exploration of researchers, the number will increase.

       "However, the current synthesis of molecular imaging probes lags far behind the speed of clinical application and research." Professor Zhang Hong said that single function and high synthesis dose are the main drawbacks of the current molecular image probe synthesis.

       For this reason, Professor Zhang Hong led the team to put forward the design idea of "PET molecular image probe microfluidic modular integrated synthesis system", which lasted for 12 years. Taking advantage of interdisciplinary advantages, it broke through many technical problems such as the manufacturing process of highly reliable organic reaction microfluidic chips, and finally realized the research and development of finished products. After verification, compared with the existing large-scale equipment, the research and development achievements of Zhang Hong's team are only the size of the computer host, which reduces the key energy consumption indicators such as preparation time, solvent consumption, equipment cost by 62% to 98%.

       "We have developed different microfluidic chip reactors, which can be manufactured for different molecular image probes by replacing the microfluidic chip." Zhang Hong explained that each chip is like a tape, and different probes can be obtained by inserting different chips.