In the hot summer, long skirts should be elegant and shorts should be cool. However, there are such a group of people, because of their rashes, patches and dandruff, even if they are full of sweat, they have to wrap themselves in long clothes and trousers; some people can't work or even dare not go out of the house. It turns out that they suffer from psoriasis, known as "immortal cancer". Psoriasis, commonly known as psoriasis, is a chronic, non infectious, stubborn and recurrent disease related to the immune system. "There is no cure for psoriasis, and patients often need lifelong treatment to control and stabilize the disease and slow down the development process." Zhang Jianzhong, former chairman of Dermatology and Venereology branch of Chinese Medical Association and director of Dermatology Department of Peking University People's Hospital, introduced.

　　There are more than 6.5 million patients in China, and the incidence is greatly affected by genetics and environment

　　The data shows that the prevalence of psoriasis in China is about 0.47%, the number of patients is more than 6.5 million, about 57.3% of the disease has developed to moderate or severe. Psoriasis often occurs in the skin, fingernails, palms, face and other parts of the body. Most of the skin damage is symmetrical, with clear boundary, erythema and plaque, usually covered with white or silver scales, which can cause itching and tingling. Professor Zhang Jianzhong said that psoriasis has a variety of causes, the most important of which are genetic factors and acquired factors. Some data show that both parents have psoriasis, and the genetic probability of children is about 40% - 50%; the genetic probability of children with psoriasis is about 10% - 20%. "Psoriasis can occur at any age. The prevalence of psoriasis is similar between men and women. About 2 / 3 of patients develop psoriasis before the age of 40. In addition to genetic factors, it is also related to environmental factors such as dampness, trauma, drinking, mental stress and other factors. "

　　The data shows that the prevalence of psoriasis in China is about 0.47%, the number of patients is more than 6.5 million, about 57.3% of the disease has developed to moderate or severe. Psoriasis often occurs in the skin, fingernails, palms, face and other parts of the body. Most of the skin damage is symmetrical, with clear boundary, erythema and plaque, usually covered with white or silver scales, which can cause itching and tingling. Professor Zhang Jianzhong said that psoriasis has a variety of causes, the most important of which are genetic factors and acquired factors. Some data show that both parents have psoriasis, and the genetic probability of children is about 40% - 50%; the genetic probability of children with psoriasis is about 10% - 20%. "Psoriasis can occur at any age. The prevalence of psoriasis is similar between men and women. About 2 / 3 of patients develop psoriasis before the age of 40. In addition to genetic factors, it is also related to environmental factors such as dampness, trauma, drinking, mental stress and other factors. "

　　The data shows that the prevalence of psoriasis in China is about 0.47%, the number of patients is more than 6.5 million, about 57.3% of the disease has developed to moderate or severe. Psoriasis often occurs in the skin, fingernails, palms, face and other parts of the body. Most of the skin damage is symmetrical, with clear boundary, erythema and plaque, usually covered with white or silver scales, which can cause itching and tingling. Professor Zhang Jianzhong said that psoriasis has a variety of causes, the most important of which are genetic factors and acquired factors. Some data show that both parents have psoriasis, and the genetic probability of children is about 40% - 50%; the genetic probability of children with psoriasis is about 10% - 20%. "Psoriasis can occur at any age. The prevalence of psoriasis is similar between men and women. About 2 / 3 of patients develop psoriasis before the age of 40. In addition to genetic factors, it is also related to environmental factors such as dampness, trauma, drinking, mental stress and other factors. "

　　The medical cost and social burden of psoriasis should not be underestimated. The report shows that the total medical expenditure of psoriasis patients accounts for 20% of the annual income, and the annual hospitalization rate is 13% (the hospitalization rate of moderate and severe patients is 26%). At the same time, 37% of the patients were unemployed due to psoriasis, 73% of the patients said that their work efficiency was reduced due to psoriasis, and the unemployment rate of the patients with moderate and severe psoriasis was as high as 48%; the patients' biggest demand for treatment was rapid skin repair, normal participation in social activities or work, and low treatment costs.

　　The new generation of biological agents is safe and effective, and experts suggest that they be included in the medical insurance reimbursement

　　The main types of psoriasis are vulgaris, pustules, erythroderma and joint psoriasis. Plaque psoriasis accounts for 80% - 90% of psoriasis, which is the most common form of psoriasis. In addition to skin symptoms, patients with moderate to severe psoriasis can be combined with other related diseases, such as metabolic syndrome, cardiovascular disease, etc., known as psoriasis comorbidity. With the deepening of research, psoriasis comorbidity from the initial combination of diabetes, cardiovascular disease, obesity, arthritis, to gradually recognize that the risk of autoimmune disease, mental disease and some liver and kidney diseases increased.

　　In China, the traditional treatment of psoriasis includes local treatment (i.e. external medication), light therapy and systemic treatment (immunosuppressive agents and biological agents). Topical drugs can be used intermittently or for a long time. The duration of treatment depends on the effect and adverse reactions of drugs, mainly including glucocorticoids, vitamin D derivatives, retinoids and calcineurin inhibitors. Physical therapy includes ultraviolet and laser therapy. In recent years, with the development of medicine, a variety of biological agents for the pathogenesis of psoriasis have been developed, which can be used to treat moderate and severe psoriasis, mainly including tumor necrosis factor - α inhibitors and new types of interleukin inhibitors. Clinical research shows that biological agents have the characteristics of safety, high efficiency, rapid action and less adverse reactions. And biological agents are constantly improving. Among them, the new biological agents which act on the targets of interleukin have obvious advantages in the treatment of moderate and severe psoriasis.

　　"Take scuchiumab, an all human IL-17A inhibitor. For Chinese patients, it has done a phase III clinical study, and I am the national leader of this study. According to the study, nearly 90% of Chinese patients with moderate or severe psoriasis who received 300 mg of scuchiumab achieved skin lesions clearance or almost clearance in the 16th week, with better data than other countries and regions. " Professor Zhang Jianzhong said, "since the new generation of IL inhibitors came into China in 2019, nearly 10000 patients have benefited. From the perspective of the effectiveness and safety of clinical application, I believe that the IL inhibitors are the future trend of the treatment of psoriasis

Finally, Professor Zhang Jianzhong suggested: "last year, three tumor necrosis factor - α inhibitors were included in the medical insurance. I hope that the new generation of interleukin inhibitors will also enter this year. In addition, it is hoped that the manufacturer would also better reduce the price a little, so that more patients can enjoy the achievements of modern medical progress. "